Soleil Research™

Medtronic Guardian Sensor 3 glucose sensor and Guardian Link 3 transmitter attached to skin, illustrating the CGM system used in the SIGNAL trial.
Continuous Glucose Monitoring Alerts in the Hospital: What the SIGNAL Trial Found
In the SIGNAL randomized trial of 533 hospitalized adults with diabetes, simple CGM threshold alerts modestly increased time in range compared with real-time CGM with alerts off. Adding predictive alerts... Read more...
Physician using a computer-based clinical information system, illustrating the clinical decision-support context of the SHAKED emergency-department study.
AI Decision Support in the Emergency Department: What the SHAKED Study Found
A prospective Nature Medicine evaluation of SHAKED followed 1,138 emergency-department patients. Sampled outputs were usually judged appropriate, but clinician adoption fell from 68% to 30%, highlighting the gap between technical... Read more...
Illustration of induced pluripotent stem cells, representing the cell source used to derive cardiomyocytes studied in the HEAL-CHF trial for advanced ischemic heart failure.
Stem Cell-Derived Cardiomyocytes in Advanced Heart Failure: What the HEAL-CHF Trial Found
HEAL-CHF tested hiPSC-derived cardiomyocytes during CABG in 20 patients. Some functional signals improved, but early ventricular arrhythmias raise caution. Read more...
NIH BioArt illustration of a blood platelet with surface projections
Cold-Stored Platelets Up to 21 Days: What the CHIPS Trial Found
The phase 3 CHIPS randomized trial found that cold-stored platelets kept for up to 21 days met prespecified noninferiority criteria for hemostatic efficacy versus standard room-temperature platelets in active bleeding... Read more...
Hospital patient receiving supplemental oxygen via nasal cannula with pulse oximeter monitoring and automated oxygen titration device — illustrating the SAVE-O₂ AI randomized clinical trial on autonomous oxygen management in acutely ill adults.
Autonomous Oxygen Titration in Acutely Ill Adults: What the SAVE-O₂ AI Trial Actually Demonstrated
The SAVE-O₂ AI randomized trial found that closed-loop oxygen titration substantially improved time within a target normoxemia range in acutely ill hospitalized adults. The study did not establish reductions in... Read more...
Overview of the PRISM2 multimodal pathology foundation model and clinical dialogue prediction tasks from Vorontsov et al., Nature Medicine 2026, used under CC BY 4.0.
PRISM2 in Digital Pathology: Can Clinical Dialogue Improve Whole-Slide Cancer Detection?
Soleil Research critically reviews PRISM2, a Nature Medicine multimodal pathology foundation model trained on more than 2.3 million whole-slide images and clinical dialogue, examining its cancer-detection performance, methodological strengths, reproducibility... Read more...
Scientific illustration for Soleil Research review of high-accuracy sequencing and detection of rare low-frequency genetic variants.
Detecting Rare Genetic Variants: How High-Accuracy Sequencing Pushes Beyond NGS Error Limits
Soleil Research reviews high-accuracy sequencing strategies for detecting low-frequency genetic variants, including single-strand and duplex consensus methods and the analytical challenge of distinguishing true molecular signals from NGS errors. Read more...
Scientific illustration for Soleil Research review of ensartinib in resected ALK-positive non-small-cell lung cancer.
Precision Medicine in Action: Ensartinib Reduces Disease Recurrence in Resected ALK-Positive Non–Small-Cell Lung Cancer
🔬 Soleil Research | High Impact ResearchFriday Edition — August 8, 2026📚 Original ReferenceZhou C, et al. Ensartinib in Resected ALK-Positive Non–Small-Cell Lung Cancer. The New England Journal of Medicine.... Read more...
Scientific illustration for Soleil Research review of cardiac myosin binding protein C, cMyC, as a cardiovascular biomarker.
A New Cardiac Biomarker Beyond Troponin: Cardiac Myosin Binding Protein C Shows Prognostic Value in the General Population
💪 Soleil Research | Laboratory MedicineWednesday Edition — August 6, 2026📚 Original ReferenceRøsjø H, et al. Prognostic Value of Cardiac Myosin Binding Protein C in the General Population: The Akershus... Read more...
Scientific illustration for Soleil Research review of MASLD biomarkers, liver biopsy alternatives, blood testing, and imaging.
Can Blood Tests and Imaging Reduce the Need for Liver Biopsy in MASLD?
A critical Soleil Research review of the 2026 LITMUS Imaging Study in Nature Medicine, examining NIS2+, magnetic resonance elastography, VCTE and Agile scores as non-invasive tools for MASH and fibrosis... Read more...