USMLE Step 1 Physiology Review

Master Physiology for USMLE Step 1

The USMLE Step 1 Physiology Review covers the functional mechanisms of every organ system tested on Step 1. Understanding physiology is the key to understanding pathology — this guide builds that foundation systematically.

Topics Covered

• Cardiovascular: cardiac cycle, action potentials, Frank-Starling law, pressure-volume loops, hemodynamics
• Respiratory: lung volumes, V/Q matching, oxygen-hemoglobin dissociation curve, acid-base regulation
• Renal: GFR, tubular reabsorption and secretion, concentration and dilution, acid-base balance
• Gastrointestinal: motility, secretion, digestion, absorption, liver function
• Endocrine: hypothalamic-pituitary axis, thyroid, adrenal, pancreatic hormones, calcium regulation
• Neurophysiology: action potentials, synaptic transmission, sensory and motor pathways, reflexes
• Musculoskeletal: muscle contraction, neuromuscular junction, smooth vs. skeletal muscle
• Reproductive: menstrual cycle, pregnancy physiology, male reproductive hormones
• Hematology: erythropoiesis, hemostasis, coagulation cascade
• High-yield graphs, equations, and clinical correlations throughout

Soleil Scientific Rating™

⭐⭐⭐⭐⭐ — Physiology is the language of medicine. Speak it fluently and pathology becomes intuitive.

Advancing Science. Empowering People. — Soleil Scientific Group