USMLE Step 1 Biochemistry & Genetics Review

Master Biochemistry & Genetics for USMLE Step 1

The USMLE Step 1 Biochemistry & Genetics Review covers the molecular and genetic foundations of medicine tested on Step 1. From metabolic pathways to inheritance patterns, this guide connects biochemistry to clinical disease.

Topics Covered

• Molecular Biology: DNA replication, transcription, translation, mutations, DNA repair
• Metabolism: glycolysis, TCA cycle, oxidative phosphorylation, gluconeogenesis
• Lipid Metabolism: fatty acid synthesis and oxidation, ketone bodies, cholesterol synthesis
• Amino Acid Metabolism: urea cycle, amino acid derivatives, one-carbon metabolism
• Vitamins & Cofactors: fat-soluble and water-soluble vitamins, deficiency diseases
• Enzyme Kinetics: Michaelis-Menten, competitive vs. non-competitive inhibition
• Genetics: Mendelian inheritance, autosomal dominant and recessive disorders
• X-linked disorders: hemophilia, Duchenne, G6PD deficiency, fragile X
• Chromosomal disorders: Down syndrome, Turner, Klinefelter, DiGeorge
• Population genetics: Hardy-Weinberg, linkage disequilibrium
• Molecular techniques: PCR, FISH, Southern blot, CRISPR, gene therapy

Soleil Scientific Rating™

⭐⭐⭐⭐⭐ — Biochemistry connects the molecular to the clinical. Master it and you understand why disease happens at its deepest level.

Advancing Science. Empowering People. — Soleil Scientific Group